New COVID19 Variants Don't Change the Rules of the Game

A day-long virtual meeting of scientists from around the globe, convened by the World Health Organization (WHO) on Tuesday, brought together more than 1,750 experts from 124 countries to discuss critical knowledge gaps and research priorities for emerging variants of SARS-CoV-2, the virus that causes COVID19.

Welcoming them, Dr Tedros Adhanom Ghebreyesus, WHO Director-General, said, “Science and research have played a vital role in responding to the pandemic since day one and will continue to be the heartbeat of everything WHO does.”

The consultation was structured around six thematic areas covering epidemiology and mathematical modelling, evolutionary biology, animal models, assays and diagnostics, clinical management and therapeutics and vaccines.

Scientists noted the importance of research to detect and understand early on the potential impact of emerging variants on diagnostics, treatments and vaccines.

Johns Hopkins University of Medicine: As of 13:22 Thailand time (06:22 GMT) on 13 Jan 2021 there were 91,605,941 confirmed #COVID19 cases (+711,144 since 13:22 Thai time on 12 Jan), 1,962,345 deaths (+17,591) and 50,630,212 people have recovered (+343,532) https://t.co/yaKDhUGmx7 pic.twitter.com/BPnHdh2QvH

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There was a consensus on the importance of integrating the new SARS-CoV-2 variants research into the global research and innovation agenda while enhancing coordination across disciplines.

“Our collective goal is to get ahead of the game and have a global mechanism to quickly identify and study variants of concern and understand their implications for disease control efforts,” said Dr Ana Maria Henao Restrepo, Head of WHO’s R&D Blueprint.

It is normal for viruses to mutate, but the more the SARS-CoV-2 virus spreads, the more opportunities it has to change. High levels of transmission mean that we should expect more variants to emerge.

Of the significant variants reported so far, two in particular - B.1.1.7. and 501Y.V2 - are associated with increases in transmissibility but not disease severity. Research is ongoing to address whether the changes impact public health tools and measures.

Genomic sequencing has been critical in identifying and responding to new variants.

“So far an astounding 350,000 sequences have been publicly shared, but most come from just a handful of countries. Improving the geographic coverage of sequencing is critical for the world to have eyes and ears on changes to the virus,” said Dr Maria Van Kerkhove, WHO Technical Lead on COVID19.

Increasing sequencing capacity across the world is a priority research area for WHO.

Better surveillance and laboratory capacity to monitor strains of concern needs to be accompanied by prompt sharing of virus and serum samples via globally agreed mechanisms so that critical research can be promptly initiated each time.

Scientists highlighted the importance of national data platforms to document critical clinical, epidemiological and virus data that facilitates the detection and assessment of new SARS-CoV-2 variants.

Whilst some of the new variants are causing a great deal of concern, Dr. Mike Ryan, Executive Director, WHO Health Emergencies Programme, says they have not changed the game. Speaking at the WHO's press conference on Monday, Dr. Ryan said, “This is like adding a substitute in the second half of a football game. It doesn't change the rules of the game, it doesn't change what you do, but it gives the virus some new energy, some new impetus. It adds to the challenge you face because the opposition is bringing on some new players to the field. It doesn't change the rules of the game though. It doesn't change what we need to do to win. It just changes the strength of the opponent, and in that sense we have to take from that we just need to redouble our efforts.”

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